Biography

Dr. Wing-Fu Lai currently is an Assistant Professor in School of Life and Health Sciences at the Chinese University of Hong Kong, Shenzhen. Before he joined LHS, he had pursued his postdoctoral training at Yonsei University in Seoul and at the University of Hong Kong. Dr. Lai has also worked as a faculty member in School of Pharmaceutical Sciences at Shenzhen University and an Adjunct Assistant Professor in Department of Applied Biology & Chemical Technology at the Hong Kong Polytechnic University. In 2018, he was accredited as Shenzhen Municipal “Overseas High-caliber Personnel” (Category B). Dr. Lai also qualified as a Chartered Chemist by the Royal Society of Chemistry in the UK in 2018, and as a Chartered Biologist by the Royal Society of Biology in 2014. In 2019, Dr. Lai was accrediated as the "High-level Talents" (Category B) in Nanshan District of Shenzhen. 


The focus of his research is to apply both chemical and engineering techniques to develop polymeric materials for biomedical and pharmaceutical applications. Some of his works on materials chemistry and engineering have been published in international journals such as Advanced Functional Materials, Chemistry of Materials, Nanoscale, ACS Applied Materials and Interfaces, Biomaterials, and Journal of Controlled Release, and have been patented in Korea and the US. He has also authored one monograph (published by Academic Press/Elsevier) on the design and engineering of delivery technologies for the development of biogerontological interventions. Apart from this, Dr. Lai has served as an ad-hoc reviewer for over 30 international journals, including ACS Applied Materials & Interfaces, Acta Biomaterialia, Ageing Research Reviews, Biomaterials, Biomacromolecules, Journal of Controlled Release, and Journal of Materials Chemistry B. 
Academic Publications

1. Lai, W. F.*, Lin, M., Wong, W. T. (2019). Tackling aging by using microRNA as a target and a tool. Trends in Molecular Medicine. DOI: 10.1016/j.molmed.2019.04.007
2. Lai, W. F.*, Hu, C. S., Deng, G. X., Lui, K. H., Wang, X., Tsoi, T. H., Wang, S. X.*, Wong, W. T.* (2019). A biocompatible and easy-to-make polyelectrolyte dressing with tunable drug delivery properties for wound care. International Journal of Pharmaceutics, 566, 101-110.
3. Li, T. Z., Wang, Z. G., Jiang, D. F., Wang, H. G., Lai, W. F., Lv, Y. K., Zhai, Y. G. (2019). A FRET biosensor based on MnO2 nanosphere/copper nanocluster complex: from photoluminescence quenching to recovery and magnification. Sensors and Actuators B: Chemical, 290, 535-543.
4. Shi, Y. E, Zhuang, X. M., Cao, L. L., Gou, S. Y., Xiong, Y., Lai, W. F., Wang, Z. G., Rogach, A. L. (2019). Copper nanocluster based transparent ultraviolet shielding polymer films. ChemNanoMat, 5, 110-115.
1. Lai, W. F.*, Lin, M. C., Tang, G. P.* (2018). A phytochemical-based copolymer derived from Coriolus versicolor polysaccharopeptides for gene delivery. Molecules, 23(9), 2273.
2. Wang, Z. G., Shi, Y. E., Yang, X. M., Xiong, Y., Li, Y. X., Chen, B. K., Lai, W. F.*, & Rogach, A. L.* (2018). Water-soluble biocompatible copolymer hypromellose grafted chitosan able to load exogenous agents and copper nanoclusters with aggregation induced emission. Advanced Functional Materials, 28(34), 1802848.
3. Lai, W. F.*, & Wong, W. T. (2018). Design of polymeric gene carriers for effective intracellular delivery. Trends in Biotechnology, 36(7), 713-728.
4. Lai, W. F.*, Rogach, A. L., Wong, W. T. (2018). One-pot synthesis of an emulsion-templated hydrogel-microsphere composite with tunable properties. Composites Part A: Applied Science and Manufacturing, 113, 318-329.
5. Li, Y., He, Z. D., Zheng, Q. E., Hu, C. S., Lai, W. F.* (2018). Hydroxypropyl-β-cyclodextrin for delivery of baicalin via inclusion complexation by supercritical fluid encapsulation. Molecules, 23, 1169.
6. Lin, J. L., Hu, C. S., He, J. X., Fu, Q. H., Huang, N. N., Chen, D. S., Lai, W. F., Liu, X. Y., Liu, Z. G. (2018). Cathepsin D as a new allergen from Dermatophagoides farina. International Journal of Clinical and Experimental Medicine, 11(11), 11804-11815.
7. Lai, W. F.*, Susha, A. S., Rogach, A. L., Wang, G. A., Hu, W. J., Huang, M. J., Wong, W. T.* (2017). Electrospray-mediated preparation of compositionally homogeneous core-shell hydrogel microspheres for sustained drug release. RSC Advances, 7(70), 44482-44491.
8. Lai, W. F.*, & Rogach, A. (2017). Hydrogel-based materials for delivery of herbal medicines. ACS Applied Materials & Interfaces, 9(3), 11309-11320.
9. Wang, Z. G., Xiong, Y., Kershaw, S., Chen, B. K., Yang, X. M., Goswami, N., Lai, W. F., Xie, J. P., Rogach, A. (2017). In situ fabrication of flexible, thermally stable, large area, strongly luminescent copper nanocluster/polymer composite films. Chemistry of Materials, 29(23), 10206-10211.
10. Lai, W. F.*, Rogach, A., & Wong, W. T.* (2017). Molecular design of upconversion nanoparticles for gene delivery. Chemical Science, 8(11), 7339-7358.
11. Lai, W. F.*, Susha, A., & Rogach, A. (2016). Multi-compartment microgel beads for co-delivery of multiple drugs at individual release rates. ACS Applied Materials & Interfaces, 8(1), 871-880.
12. Lai, W. F.*, & Shum, H. C.* (2016). A stimuli-responsive nanoparticulate system using poly(ethylenimine)-graft-polysorbate for controlled protein release. Nanoscale, 8(1), 517-528.
13. Lai, W. F.*, & He, Z. D.* (2016). Design and fabrication of hydrogel-based nanoparticulate systems for in vivo drug delivery. Journal of Controlled Release, 243, 269-282.
14. Lai, W. F., & Lin, M. C. M. (2015). Chemotherapeutic drugs interfere with gene delivery mediated by chitosan-graft-poly(ethylenimine). PLoS One, 10(5), e0126367.
15. Lai, W. F., Oka, K., & Jung, H. S. (2015). Advanced functional polymers for regenerative and therapeutic dentistry. Oral Diseases, 21(5), 550-557.
16. Lai, W. F.*, & Lin, M. C. M. (2015). Treating cutaneous aging with patented technologies. Journal of Biosciences, 40(2), 209-216.
17. Lai, W. F., & Lin, M. C. M. (2015). Folate-conjugated chitosan-poly(ethylenimine) copolymer as an efficient and safe vector for gene delivery in cancer cells. Current Gene Therapy, 15(5), 472-480.
18. Lai, W. F.* (2015). Microfluidic methods for non-viral gene delivery. Current Gene Therapy, 15(1), 55-63.
19. Lai, W. F., & Shum, H. C. (2015). Hypromellose-graft-chitosan and its polyelectrolyte complex as novel systems for sustained drug delivery. ACS Applied Materials & Interfaces, 7(19), 10501-10510.
20. Lai, W. F.* (2014). Cyclodextrins in non-viral gene delivery. Biomaterials, 35(1), 401-411.
21. Lai, W. F., Lee, J. M., & Jung, H. S. (2014). Molecular and engineering approaches to regenerate and repair teeth in mammals. Cellular and Molecular Life Sciences, 71(9), 1691-1701.
22. Lai, W. F.*, & Siu, P. M. (2014). MicroRNAs as regulators of cutaneous wound healing. Journal of Biosciences, 39(3), 519-524.
23. Lai, W. F., Green, D. W., & Jung, H. S. (2014). Linear poly(ethylenimine) cross-linked by methyl-β-cyclodextrin for gene delivery. Current Gene Therapy, 14(4), 258-268.
24. Lai, W. F., & Jung, H. S. (2014). Cell transfection with a β-cyclodextrin-PEI-propane-1,2,3-triol nanopolymer. PLoS One, 9(6), e100258.
25. Green, D. W., Lai, W. F., & Jung, H. S. (2014). Evolving marine biostructures for regenerative medicine. Marine Drugs, 12(5), 2877-2912.
26. Lee, J. M., Kwon, H. J., Lai, W. F., & Jung, H. S. (2014). Requirement of Runx3 in pulmonary vasculogenesis. Cell and Tissue Research, 356(2), 445-449.
27. Wang, P. W., Lai, W. F., Li, M. J., Xu, F., Yalamanchili, H. K., Lovell-Badge, R., & Wang, J. W. (2013). Inference of gene-phenotype associations via protein-protein interaction and orthology. PLoS One, 8(10), e77478.
28. Lai, W. F.* (2013). Nucleic acid delivery: roles in biogerontological interventions. Ageing Research Reviews, 12(1), 310-315.
29. Lai, W. F.* (2012). Protein kinases as targets for interventive biogerontology: overview and perspectives. Experimental Gerontology, 47(4), 290-294.
30. Lai, W. F.* (2011). In vivo nucleic acid delivery with PEI and its derivatives: current status and perspectives. Expert Review of Medical Devices, 8(2), 173-185.
31. Lai, W. F.*, & Chan, Z. C. Y. (2011). Beyond sole longevity: a social perspective on healthspan extension. Rejuvenation Research, 14(1): 83-88.
32. Lai, W. F.* (2011). Nucleic acid therapy for lifespan prolongation: present and future. Journal of Biosciences, 36(4), 725-729.
33. Chan, Z. C. Y. ?,*, & Lai, W. F.?,* (2009). Revisiting the melamine contamination event in China: implications for ethics in food technology. Trends in Food Science and Technology, 20(8), 366-373. (? Equal first authorship)
34. Lai, W. F.*, & Lin, M. C. M. (2009). Nucleic acid delivery with chitosan and its derivatives, Journal of Controlled Release, 134(3), 158-168.