Biography

Xiao-Shui Peng received his BSc and MSc degrees from Lanzhou University in 1999 and 2002, respectively, under the guidance of Professor Xin-Fu Pan. In 2006, he obtained his PhD from The Chinese University of Hong Kong, where he worked on the total synthesis of pallavicinin under the supervision of Henry N. C. Wong. After completing his postdoctoral research fellowship with Professors K. C. Nicolaou and David Y. K. Chen on the cortistatin project at CSL@Biopolis, Singapore, he returned to CUHK as Research Assistant Professor (2009-2015) and Research Associate Professor (2015-2020). In 2020, he joined School of Science and Engineering as Associate Professor at The Chinese University of Hong Kong (Shenzhen), and is focusing his research themes on the development of novel “bio-inspired” strategies and synthetic methodologies for the total synthesis of structurally complex and biologically significant natural products, as well as natural product-derived drug discovery.


Positions Available (PhD Students, Postdoctoral Researchers)

We are looking for PhD Students, Postdoctoral Fellows with research background in Organometallic, Synthetic Methodology, Natural Product Synthesis, and will provide full financial support to the successful applicants. 

Applicants for PhD postgraduate studentship should provide a resume with transcript (GPA higher than 80/100 or 3.2/4.0, 211/985 universities) and grade of TOEFL or IELTS English test (TOEFL 550 (paper-based)/TOEFL 79 (internet-based)/IELTS Band 6.5). 

Applicants should send the application package to Prof. Peng at xspeng@cuhk.edu.hk. 



Research

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1. Total Synthesis of Structurally Complex and Biologically Significant Natural Products

2. Eco-friendly Catalytic Methodologies for Target-Oriented Synthesis

3. Natural Product-Derived Drug Discovery  



Academic Publications
  1. 1. Total Synthesis of CryptotrioneLyu, M.-Y.; Zhong, Z.; Lo, V. K. L.; Wong, H. N. C.;* Peng, X.-S.Angew. Chem., Int. Ed. 20205910.1002/anie.202009255. 

  2. 2. Total Syntheses of (-)-Deoxoapodine, (-)-Kopsifoline D, and (-)-Beninine. Zhou, Y. G.; Wong, H. N. C. *Peng, X. S. *J. Org. Chem. 202085, 967-976.

  3. 3. PtCl2-Catalyzed Cycloisomerization of 1,8-Enynes: Synthesis of Tetrahydropyridine Species. Mirzaei, A.; Peng, X.-S.;* Wong, H. N. C.* Org. Lett. 201921, 3795-3798.

  4. 4. Stereospecific Iron-Catalyzed Carbon(sp2)–Carbon(sp3) Cross-Coupling with Alkyllithium and Alkenyl Iodide. Lu, X.-L.; Shannon, M.; Peng, X.-S.;* Wong, H. N. C.* Org. Lett. 201921, 2546-2549.

  5. 5. Ligand-Free Iron-Catalyzed Carbon (sp2)–Carbon (sp2) Oxidative Homo-Coupling of Alkenyllithiums. Zhong, Z.; Wang, Z.-Y.; Ni, S.-F.; Dang, L.;* Lee, H. K.; Peng, X.-S.;* Wong, H. N. C.* Org. Lett. 201921, 700-704.

  6. 6. Total syntheses of shizukaols A and E. Wu, J.-L.; Lu, Y.-S.; Tang, B.-C.;* Peng, X.-S.* Nat. Commun. 20189, 4040. DOI.10.1038/s41467-018-06245-7.

  7. 7. Gold(I)-Catalyzed Tandem Cycloisomerization of 1,5-Enyne Ethers by Hydride Transfer. Lu, X.-L.; Lyu, M.-Y.; Peng, X.-S.;* Wong, H. N. C.* Angew. Chem., Int. Ed., 201857, 11365-11368.

  8. 8. Synthesis of tetraphenylene derivatives and their recent advances. Han, J. W.; Peng, X.-S.; Wong, H. N. C. Nat. Sci. Rev. 20174, 892-916.

  9. 9. Iron-catalysed cross-coupling of organolithium compounds with organic halides. Jia, Z.-H.; Liu, Q.; Peng, X.-S.; Wong, H. N. C.* Nat. Commun. 20167:10614, doi: 10.1038/ncomms10614.

  10. 10. Biomimetic total synthesis of Gracilioether F. Shen, X. –Y.; Peng, X.-S.; Wong, H. N. C.* Org. Lett. 2016, 18, 1032-1035.