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My WeChat ID is RNA-CHEN

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Patents Filed

5.  PCT专利，PCT/CN2024/115426,  Title: 靶向RNA 的组合物及其用途 (Chimeras for targeting RNA and uses thereof) 发明人：陈刚、鲁荣光、邓莉萍、廉云、占轩、杨利霞、林芮羽、范诗健。申请人：香港中文大学（深圳）；香港中文大学（深圳）福田生物医药创新研发中心

4. 中国专利，申请号：202311069752.9, 基于G-四链体的核酸分子及其应用。发明人：陈刚、占轩、廉云、邓莉萍、鲁荣光、王安妮、白诗瑶、蒋成。申请人：香港中文大学（深圳）；香港中文大学（深圳）福田生物医药创新研发中心


3. 中国专利申请号：202311137198.3, 靶向RNA 的组合物及其用途。发明人：陈刚、鲁荣光、邓莉萍、廉云、占轩、杨利霞、林芮羽、范诗健。申请人：香港中文大学（深圳）；香港中文大学（深圳）福田生物医药创新研发中心

2. PCT专利，PCT/SG2020/050380, Title: Inhibitors of RNA Editing and Uses Thereof.  WO2021002805  
National Phase Entry:
Singapore (Dec 23, 2021); 
European Patent Office (Feb 4, 2022);
China Patent Office (Mar 3, 2022);
US Patent Office (December 24, 2022)
Inventors: 1) Leilei CHEN; 2) Daryl Jin Tai TAY; 3) Gang CHEN 
Applicants: 1) National University of Singapore; 2) Nanyang Technological University

1. PCT专利，PCT/SG2015/050319,  Title: Modified Peptide Nucleic Acids And Their Use. 
Inventors: 1) Gitali DEVI; 2) Desiree-Faye TOH Kaixin; 3) Kiran M. PATIL; 4) QU Qiuyu; 5) Manikantha MARASWAMI; 6) Elzbieta KIERZEK; 7) XIAO Yunyun; 8) LOH Teck Peng; 9) ZHAO Yanli; 10) CHEN Gang
Applicants: 1) Nanyang Technological University; 2) Institute of Bioorganic Chemistry Polish Academy of Sciences.

Book Chapters

 1. Patil, K.M., and Chen, G. (2016) Recognition of RNA sequence and structure by duplex and triplex formation: targeting miRNA and pre-miRNA, in Modified Nucleic Acids in Biology and Medicine, (Volker A. Erdmann, Stefan Jurga and Jan Barciszewski, Eds.), Springer series: RNA Technologies. Doi: 10.1007/978-3-319-34175-0_13

Journal Papers 

50.     Rongguang Lu, Liping Deng, Yun Lian, Xin Ke, Lixia Yang, Kun Xi, Alan Ann Lerk Ong, Yanyu Chen, Hanting Zhou, Zhenyu Meng, Ruiyu Lin, Shijian Fan, Yining Liu, Desiree-Faye Kaixin Toh, Xuan Zhan, Manchugondanahalli S. Krishna, Kiran M. Patil, Yunpeng Lu, Zheng Liu, Lizhe Zhu, Hongwei Wang, Guobao Li* and Gang Chen* (2024) Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform. Cell Rep Phys Sci, 5, 102150. (Cell Press, IF: 7.9)

49.     Xuan Zhan, Liping Deng, Yun Lian, Zhiyu Shu, Yunong Xu, Xinyi Mai, Manchugondanahalli S. Krishna, Rongguang Lu, Anni Wang, Shiyao Bai, Fangyu Zhou, Chi Xiong, Yingyi Xu, Jie Ni, J. Jeya Vandana, Dongmei Sun, Shaohui Huang, Jingyan Liu, Gui-Juan Cheng, Song Wu, Ying-Chih Chiang,* Stjepanovic Goran,* Cheng Jiang,* Yong Shao* and Gang Chen* (2024) Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure. Anal Chem, 96, 13174-13184.(ACS journal, IF: 7.4) 

48.     Rongguang Lu, Gang Chen* (2024) Pre-twisting for improved genome modification and miRNA targeting. Trends Biochem Sci, 49, 283-285. Spotlight article (Cell Press, IF: 14.264) 

47.     Xuan Zhan, Liping Deng, and Gang Chen* (2022) Mechanisms and applications of peptide nucleic acids (PNAs) selectively binding to dsRNA. Biopolymers, 113, e23476.

Invited contribution to a special issue on 30 years of PNA.

46.     Daryl Jin Tai Tay, Yangyang Song, Boya Peng, Tan Boon Toh, Lissa Hooi, Desiree-Faye Kaixin Toh, Huiqi Hong, Sze Jing Tang, Jian Han, Wei Liang Gan, Tim Hon Man Chan, Manchugondanahalli S. Krishna, Kiran M. Patil, Manikantha Maraswami, Teck Peng Loh, Yock Young Dan, Lei Zhou, Glenn Kunnath Bonney, Pierce Kah-Hoe Chow, Gang Chen, Edward Kai-Hua Chow, Minh TN. Le, Leilei Chen* (2021) Targeting RNA Editing of Antizyme Inhibitor 1: a Potential Oligonucleotide-Based Antisense Therapy for Cancer. Mol Ther, 29, 3258-327. (IF: 8.986)

45.     Arijit Maity, Fernaldo Richtia Winnerdy, Gang Chen, and Anh Tuân Phan* (2021) Duplexes formed by G4C2 repeats contain alternate slow- and fast-flipping G-G base pairs. Biochemistry, 60, 1097-1107.

44.     Lixia Yang, Desiree-Faye Kaixin Toh, Manchugondanahalli S. Krishna, Zhensheng Zhong, Yiyao Liu, Shaomeng Wang, Yubin Gong and Gang Chen* (2020) Tertiary Base Triple Formation in the SRV-1 Frameshifting Pseudoknot Stabilizes Secondary Structure Components. Biochemistry, 59, 4429-4438.

43.     Maity, A., Winnerdy, F.R., Chang, W.D., Chen, G., and Phan, A.T.* (2020) Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs. Nucleic Acids Res. 48, 3315-3327. (IF: 11.561)

42.     Ong, A.A.L., Tan, J., Bhadra, M., Dezanet, C., Patil, K.M., Chong, M.S., Kierzek, R., Decout, J.L., Roca, X., and Chen, G.* (2019) RNA secondary structure-based design of antisense peptide nucleic acids for modulating disease-associated aberrant tau pre-mRNA alternative splicing. Molecules, 24, 3020. (IF: 3.098)

41.  Krishna, M.S., Wang, Z., Bowry, J., Wang, Z., Zheng, L., Bowry, J., Ong, A.A.L., Mu, Y., Prabakaran, M., and Chen, G.* (2019) Incorporating G-C Pair-Recognizing Guanidinium into PNAs for Sequence and Structure Specific Recognition of dsRNAs over dsDNAs and ssRNAs. Biochemistry, 58, 3777-3788. (IF: 2.997)

40.  Ong, A.A.L., Toh, D.F.K., Krishna, M.S., Patil, K.M., Okamura, K., and Chen, G.* (2019) Incorporating 2-thiouracil into short dsRNA-binding PNAs for enhanced recognition of A-U pairs and for targeting a microRNA hairpin precursor. Biochemistry, 58, 3444-3453. (IF: 2.997)

39.  Krishna, M.S., Toh, D.F.K., Meng, Z., Ong, A.A.L., Wang, Z., Lu, Y., Xia, K., Prabakaran, M., and Chen, G.* (2019) Sequence- and structure-specific probing of RNAs by short nucleobase-modified dsRNA-binding PNAs incorporating a fluorescent light-up uracil analog. Anal. Chem., 91, 5331-5338. (IF: 6.042)

38.  Tan, J., Yang, L., Ong, A.A.L., Shi, J., Zhong, Z., Lye, M.L., Liu, S., Lisowiec-Wachnicka, J., Kierzek, R., Roca, X.,* Chen, G.* (2019) A disease-causing intronic point mutation C19G alters tau exon 10 splicing via RNA secondary structure rearrangement. Biochemistry, 58, 1565-1578. (IF: 2.997)

37.  Kesy, J., Patil, K.M., Kumar, S.M. Shu, Z., Yee, Y.H., Zimmermann, L., Ong, A.A.L., Toh, D.F.K., Krishna, M.S., Yang, L., Decout, J.L., Luo, D., Prabakaran, M.,* Chen, G.,* and Kierzek, E.* (2019) A short chemically modified dsRNA-binding PNA (dbPNA) inhibits influenza viral replication by targeting viral RNA panhandle structure. Bioconjugate Chem., 30, 931-943. (IF: 4.485)

36.  Ong, A.A.L., Toh, D.F.K., Patil, K.M., Meng, Z., Yuan, Z., Krishna, M.S., Devi, G. Haruehanroengra, P., Lu, Y., Xia, K., Okamura, K., Sheng, J., and Chen, G.* (2019) General recognition of U-G, U-A, and C-G pairs by double-stranded RNA-binding PNAs incorporating an artificial nucleobase. Biochemistry, 58, 1319-1331. (IF: 2.997)

35.  Yang, L., Zhong, Z., Tong, C., Jia, H., Liu, Y., and Chen, G.* (2018) Single-molecule mechanical folding and unfolding of RNA hairpins: Effects of single A-U to A∙C pair substitutions and single proton binding and implications for mRNA structure-induced −1 ribosomal frameshifting. J. Am. Chem. Soc. 140, 8172-8184. (IF: 14.357)

34.  Patil, K.M., Toh, D.F.K., Yuan, Z., Meng, Z., Shu, Z., Zhang, H., Ong, A.A.L., Krishna, M.S., Lu, L., Lu, Y.,* and Chen, G.* (2018) Incorporating uracil and 5-halouracils into short peptide nucleic acids for enhanced recognition of A-U pairs in dsRNAs. Nucleic Acids Res. 46, 7506-7521. (IF: 11.561)

33.  Maraswami, M., Chen, G.,* and Loh, T.P.* (2018) Iridium(III)-catalyzed selective and mild C-H amidation of cyclic N-sulfonyl ketimines with organic azides. Adv. Synth. Catal. 360, 416-421. (IF: 5.123)

32.  Puah, R.Y. Jia, H., Maraswami, M., Toh, D.F.K., Ero, R., Yang, L., Patil, K.M., Ong, A.A.L., Krishna, M.S., Sun, R., Tong, C., Huang, M., Chen, X., Loh, T.P., Gao, Y.G., Liu, D.X.,* and Chen, G.* (2018) Selective binding to mRNA duplex regions by chemically modified peptide nucleic acids stimulates ribosomal frameshift. Biochemistry 57, 149-159. (IF: 2.997)

Invited for the Future of Biochemistry special issue, 
Cover highlight of 44 faces representing the Future of Biochemistry,  Editorial

31.  Maraswami, M., Pankajakshan, S., Chen, G.,* and Loh, T.P.* (2017) Palladium-catalyzed direct C-H trifluoroethylation of aromatic amides. Org. Lett. 19, 4223-4226. (IF: 6.492)

30.  Chen, H., Jia, H., Tham, H.P., Qu, Q., Xing, P., Zhao, J., Phua, S.Z.F., Chen, G.,* and Zhao, Y.* (2017) Theranostic prodrug vesicles for imaging guided co-delivery of camptothecin and siRNA in synergetic cancer therapy. ACS Appl. Mater. Interfaces 9, 23536-23543. (IF: 8.097)

29.  Toh, D.F.K., Patil, K.M., and Chen, G.* (2017) Sequence-specific and selective recognition of double-stranded RNAs over single-stranded RNAs by chemically modified peptide nucleic acids. J. Vis. Exp. 127, e56221. (IF: 1.325)

28.  Zhong, Z., Yang, L., Zhang, H., Shi, J., Vandana, J., Lam, D.T.U.H., Olsthoorn, R.C.L., Lu, L., and Chen, G.* (2016) Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for −1 ribosomal frameshifting stimulation. Sci. Rep. 6, 39549. (IF: 4.122)

27.  Toh, D.F.K., Devi, G., Patil, K.M., Qu, Q., Maraswami, M., Xiao, Y., Loh, T.P., Zhao, Y.,* and Chen, G.* (2016) Incorporating a guanidine-modified cytosine base into triplex-forming PNAs for the recognition of a C-G pyrimidine-purine inversion site of an RNA duplex. Nucleic Acids Res. 44, 9071-9082. (IF: 11.561)

26.  Tan, J., Ho, J.X.J., Zhong, Z., Luo, S., Chen, G., and Roca, X.* (2016) Noncanonical registers and base pairs in human 5’ splice-site selection. Nucleic Acids Res. 44, 3980-3921. (IF: 11.561)

25.  Guo, S., Kierzek, E., Chen, G., Zhou, Y.J., and Wong, S.K.* (2015) TMV mutants with poly(A) tracts of different lengths demonstrate structural variations in 3′UTR affecting viral RNAs accumulation and symptom expression. Sci. Rep. 5, 18412. (IF: 4.122)

24.  Zhong, Z., and Chen, G.* (2015) How RNA catalyzes cyclization. Nat. Chem. Biol. 11, 830-831. (IF: 13.843)

23.  Zhong, Z., Soh, L.H., Lim, M.H., and Chen, G.* (2015) A U∙U pair-to-U∙C pair mutation-induced RNA native structure destabilization and stretching-force-induced RNA misfolding. ChemPlusChem 80, 1267-1278. (IF: 3.205)

22.  Zhang, L., Liu, H., Shao, Y.,* Lin, C., Jia, H., Chen, G.,* Yang, D.,* and Wang, Y. (2015) Selective lighting up of epiberberine alkaloid fluorescence by fluorophore-switching aptamer and stoichiometric targeting of human telomeric DNA G-quadruplex multimer. Anal. Chem. 87, 730-737. (IF: 6.042)

21.  Devi, G., Zhou, Y., Zhong, Z., Toh, D.F.K., and Chen, G.* (2015) RNA triplexes: From structural principles to biological and biotech applications. Wiley Interdiscip. Rev. RNA 6, 111-128. (IF: 5.844)

20.  Ma, X., Devi, G., Qu, Q., Toh, D.F.K., Chen, G.,* and Zhao, Y.* (2014) Intracellular delivery of antisense peptide nucleic acid by fluorescent mesoporous silica nanoparticles. Bioconjugate Chem. 25, 1412-1420. (IF: 4.485)

19.  Devi, G., Yuan, Z., Lu, Y., Zhao, Y.,* and Chen, G.* (2014) Incorporation of thio-pseudoisocytosine into triplex-forming peptide nucleic acids for enhanced recognition of RNA duplexes. Nucleic Acids Res. 42, 4008-4018. (IF: 11.561)

18.  Zhou, Y., Kierzek, E., Loo, Z.P., Antonio, M., Yau, Y.H., Chuah, Y.W., Geifman-Shochat, S., Kierzek, R.,* and Chen, G.* (2013) Recognition of RNA duplexes by chemically modified triplex-forming oligonucleotides. Nucleic Acids Res. 41, 6664-6673. (IF: 11.561)

17.  Tinoco, I., Jr.,* Chen, G., and Qu, X. (2010) RNA reactions one molecule at a time, in RNA Worlds, (Gesteland, R.F., Cech, T.R., and Atkins, J.F., Eds.), Cold Spring Harbor Laboratory Press. Cold Spring Harb. Perspect. Biol. 2, a003624. doi: 10.1101/cshperspect.a003624. (IF: 9.274)

16.  Chen, G., Chang, K.Y., Chou, M.Y., Bustamante, C., and Tinoco, I., Jr.* (2009) Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of –1 ribosomal frameshifting. Proc. Natl. Acad. Sci. USA 106, 12706-12711. (IF: 9.504)

15.  Chen, G., Kennedy, S.D., and Turner, D.H.* (2009) A CA⁺ pair adjacent to a sheared GA or AA pair stabilizes size-symmetric RNA internal loops. Biochemistry 48, 5738-5752. (IF: 2.997)

14.  Chen, G., Wen, J.D., and Tinoco, I., Jr.* (2007) Single-molecule mechanical unfolding and folding of a pseudoknot in human telomerase RNA. RNA 13, 2175-2188. (IF: 4.490)

13.  Chen, G., Kierzek, R., Yildirim, I., Krugh, T.R., Turner, D.H.,* and Kennedy, S.D. (2007) Stacking effects on local structure in RNA: Changes in the structure of tandem GA pairs when flanking GC pairs are replaced by isoG-isoC pairs. J. Phys. Chem. B 111, 6718-6727. (IF: 3.146)

12.  Shankar, N., Kennedy, S.D., Chen, G., Krugh, T.R., and Turner, D.H.* (2006) The NMR structure of an internal loop from 23S ribosomal RNA differs from its structure in crystals of 50S ribosomal subunits. Biochemistry 45, 11776-11789. (IF: 2.997)

11.  Chen, G., Kennedy, S.D., Qiao, J., Krugh, T.R., and Turner, D.H.* (2006) An alternating sheared AA pair and elements of stability for a single sheared purine-purine pair flanked by sheared GA pairs in RNA. Biochemistry 45, 6889-6903. (IF: 2.997)

10.  Chen, G., and Turner, D.H.* (2006) Consecutive GA pairs stabilize medium-size RNA internal loops. Biochemistry 45, 4025-4043. (IF: 2.997)

9.  Chen, G., Znosko, B.M., Kennedy, S.D., Krugh, T.R., and Turner, D.H.* (2005) Solution structure of an RNA internal loop with three consecutive GA pairs. Biochemistry 44, 2845-2856. (IF: 2.997)

8.  Chen, G., Znosko, B.M., Jiao, X., and Turner, D.H.* (2004) Factors affecting thermodynamic stabilities of RNA 3 × 3 internal loops. Biochemistry 43, 12865-12876. (IF: 2.997)

7.  Cui, Y.,* Chen, G., Ren, J., Shao, M., Xie, Y., and Qian, Y.* (2003) Solvothermal syntheses of β-Ag₂Se crystals with novel morphologies. J. Solid State Chem. 172, 17-21. (IF: 2.179)

6.  Cui, Y.,* Chen, J., Chen, G., Ren, J., Yu, W., and Qian, Y. (2001) Bis(2,2-bipyridine-N,N')tetra-µ-chloro-tetracopper(I). Acta Crystallogr. Sect. C 57, 349-351. (IF: 8.678)

5.  Shao, M., Mo, M., Cui, Y., Chen, G., and Qian, Y.* (2001) The effect of agitation states on hydrothermal synthesis of Bi₂S₃ nanorods. J. Cryst. Growth 233, 799-802. (IF: 1.573)

4.  Cui, Y.,* Ren, J., Chen, G., Qian, Y.,* and Xie, Y. (2001) A simple route to synthesize MInS₂ (M = Cu, Ag) nanorods from single-molecule precursors. Chem. Lett., (3) 236-237. (IF: 1.485)

3.  Cui, Y.,* Ren, J., Chen, G., Yu, W., and Qian Y. (2000) Poly[lead(II)-µ-4,4-bipyridine-N:N'-di-µ-bromo]. Acta Crystallogr. Sect. C 56, E552-E553. (IF: 8.678)

2.  Cui, Y., Chen, G., Ren, J., Qian, Y.,* and Huang, J.* (2000) Syntheses, structures and magnetic behaviors of di- and trinuclear pivalate complexes containing both cobalt(II) and lanthanide(III) ions. Inorg. Chem. 39, 4165-4168. (IF: 4.700)

1.  Cui, Y.,* Zhang, X., Zheng, F., Ren, J., Chen, G., Qian, Y., and Huang J. (2000) Two mixed-metal carboxylate-base adducts. Acta Crystallogr. Sect. C 56, 1198-1200. (IF: 8.678)