Biography

Dr. Choi received a PhD in College of Pharmacy from Pusan National University in South Korea. She worked as a postdoctoral fellow at the University of Kansas Medical Center (Dept. of Pharmacologym Toxicology and Therapeutics, and Cancer Biology) in the USA. In 2016, she joined CHA Bundang Medical Center in South Korea as a research assistant professor. Nov. 2017, she joined Prof. Zhu's Lab in School of Life and Health Sciences, the Chinese University of Hong Kong (Shenzhen) as a research assistant professor. 


Dr. Choi focused on two important topics. The first is the role of oxidative stress and neuronal cell death on diseases of hippocampus neuronal cells. With her discovery of the specific role of each molecule in the signaling cascade, she develops neuroprotective drugs using in vitro and in vivo models. The second, she studies the mechanisms of the cell cycle, apoptosis and cell signaling pathways implicated in the chemical reactions of cancer cells and various human diseases. She has published more than 20 scientific papers related to this research.


Academic Publications

1. Choi HJ, Song JH, Stephanie C, Bishop, Chun-Feng Liu and Zhu BT [2019] Norephinephrine and Dopamine, Two Catecholamine Neurotransmitters, Have protective Effect against Glutathione Depletion-Associated Oxidative Neuronal Death. (pending revision)

2. Choi HJ, Anthony J. Lee, Ki Sung Kang, Ji Hoon Song and Bao Ting Zhu [2019] Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage. (pending revision)

3.Choi HJ, Zhu BT [2019]. Upregulated cyclin B1/CDK1 mediates apoptosis following 2-methoxyestradiol-induced mitotic catastrophe: Role of Bcl-XL phosphorylation. Steroids. 2019 Feb 22. pii: S0039-128X(19)30045-5. doi: 10.1016/j.steroids.

4. Choi HJ, Heo JH, Park JY, Jeong JY, Cho HJ, Park KS, Kim SH, Moon YW, Kim JS, An HJ [2019].  A novel PI3K/mTOR dual inhibitor, CMG002, overcomes the chemoresistance in ovarian cancer. Gynecol Oncol. 2019 Apr;153(1):135-148. doi: 10.1016/j.ygyno.

5. Ogony J, Choi HJ, Lui A, Cristofanilli M, Lewis-Wambi [2016]. Interferon-induced transmembrane protein 1 (IFITM1) overexpression enhances the aggressive phenotype of SUM149 inflammatory breast cancer cells in a signal transducer and activator of transcription 2 (STAT2)-dependent manner. Breast Cancer Res. 2016 Feb 20;18(1):25.

6. Fukui M, Yamabe N, Choi HJ, Polireddy K, Chen Q and Zhu BT [2015] Mechanism of Ascorbate-Induced Cell Death in Human Pancreatic Cancer Cells: Role of Bcl-2, Beclin 1 and Autophagy. Planta Med 2015; 81(10): 838-846. DOI: 10.1055/s-0035-1546132

7. Yee SB, Choi HJ, Chung SW, Park DH, Sung B, Chung HY and Kim ND [2015] Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway. Int J Oncol. 2015 Jun 18. doi: 10.3892/ijo.2015.3053

8. Choi HJ, Asona Lui, Joshua Ogony, Rifat Jan, Peter Sims, and Joan Lewis-Wambi [2015] Targeting interferon signaling pathway sensitizes aromatase inhibitor resistant breast cancer cells to estrogen-induced cell death. Breast Cancer Research 17(1):6. doi: 10.1186/s13058-014-0506-7

9. Choi HJ, Zhu BT [2012]. Role of cyclin B1/Cdc2 in mediating Bcl-X(L) phosphorylation and apoptotic cell death following nocodazole-induced mitotic arrest. Mol Carcinog. doi: 10.1002/mc.21956.

10.Choi HJ, Zhu BT [2012]. Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol. Biochim Biophys Acta. 1823:1306-1315. (I.F. = 5.538)

11. Fukui M, Choi HJ, Zhu BT [2012]. Rapid generation of mitochondrial superoxide induces mitochondrion-dependent but caspase-independent cell death in hippocampal neuronal cells that morphologically resembles necroptosis. Toxicol Appl Pharmacol. 262:156-166. (I.F. = 4.447)

12. Fu X, Wang P, Fukui M, Long C, Yin L, Choi HJ, Zhu BT [2012]. PDIp is a major intracellular oestrogen-storage protein that modulates tissue levels of oestrogen in the pancreas. Biochem J. 447:115-23. (I.F. = 5.016)

13. Choi HJ, Fukui M and Zhu BT [2011] Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. PLoS ONE 6: e24312. (I.F. = 4.411)

14. Choi HJ, Kang KS, Fukui M and Zhu BT [2011] Critical role of the JNK-p53-GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons. Br. J. Pharmacol. 162: 175-192. (I.F. = 5.259)

15. Fukui M, Choi HJ and Zhu BT [2010]. Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death. Free Radic. Biol. Med. 49: 800-813. (I.F. = 5.773)

16. Fukui M, Song JH, Choi J, Choi HJ and Zhu BT [2009] Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. Eur. J. Pharmacol. 617: 1-11. (I.F. = 2.737)

17. Zhou R, Fukui M, Choi HJ and Zhu BT [2009] Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: Implications for a mechanism of lifespan prolongation and cancer protection. Br. J. Pharmacol. 158: 462-474. (I.F. = 5.259)

18. Fukui M, Choi HJ, Weinman SA, Okada K and Zhu BT [2012] Mechanism of herbicide-induced neuronal death: Evidence for mitochondrial oxidative damage as the main cause. Molecular and Cellular Biochemistry (in press). (I.F. = 3.122)

19. Choi HJ, Chung YS, Kim HJ, Moon UY, Choi YH, Van Seuningen I, Baek SJ, Yoon HG and Yoon JH [2009] Signal pathway of 17β-estradiol-induced MUC5B expression in human airway epithelial cells. Am. J. Resp. Cell Mol. Biol. 40: 168-178. (I.F. = 4.109)

20. Choi HJ, Yee SB, Park SE, Im E, Jung JH, Chung HY, Choi YH and Kim ND [2006] Petrotetrayndiol A induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells through cytochrome c-mediated activation of caspases. Cancer Lett. 232: 214-225. (I.F. = 5.992)

21. Choi HJ, Choi YH, Yee SB, Im E, Jung JH and Kim ND [2005] Ircinin-1 induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells. Mol. Carcinog. 44: 162-173. (IF = 4.77)

22. Choi HJ, Bae SJ, Kim ND, Jung JH and Choi YH [2005] Induction of apoptosis by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp. in human skin melanoma cells. Int. J. Mol. Med. 14: 1091-1096. (I.F. = 1.88)

23. Park SE, Choi HJ, Yee SB, Chung HY, Suh H, Choi YH, Yoo YH and Kim ND [2004]  Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells. Int. J. Oncol. 25: 231-236. (I.F. = 2.447)

24. Choi HJ, Kim ND, Jung JH and Choi YH [2004] Regulation of Bcl-2 family and cyclooxygenases by furanoterpenoids isolated from marine sponges in human lung cancer A549 cells. Korean J. Life Sci. 14: 445-452.

25. Choi HJ, Jung MJ and Jeong YK [2002] Optimization of the production of an immunostimulant from a marine macterium. Korean J. Life Sci. 12: 759-764.

26. Choi YH and Choi HJ [2001] Significance of cell cycle and checkpoint control. Korean J. Life Sci. 11: 362-370. (review article)

27. Choi HJ, Jung MJ and Jeong YK [2000] Isolation and identification of a marine bacterium producing an immunostimulant. J. Korean Soc. Food Sci. Nutr. 29: 1145-1150.