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Hongli HU WEBSITE
Dr. Hu, Hongli received her bachelor's degree in Applied Physics from Nankai University in 2008 and her Ph.D. degree in Biophysics from Peking University in 2013. Then she continued her study on the structural biology based on Cryo-electron Electron Microscopy at the Wadsworth Center of the New York State Department of Health, the University of Michigan, and Stanford University. She conducted extensive collaborative research with Prof. Brian Kobilka and Prof. Robert Lefkowitz of 2012 Nobel Laureates in chemistry at the university of Michigan and Stanford university. Since 2017, she has published several articles in top journals such as Nature and Science with 1000 citations. Besides, two of the nature articles received broad attention and were highlighted by Nature News & Review.
In June 2019, Dr. Hu established the cryo-EM structure lab at the School of Life and Health Sciences, Chinese University of Hong Kong (Shenzhen) and the Kobilka Institute of Innovative Drug Discovery.
1. Chen, G., X. Wang, Y. Ge, L. Ma, Q. Chen, H. Liu, Y. Du, R. D. Ye, H. Hu and R. Ren. (2020). Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther 5(1): 142.
2. Staus, D.P.*, Hu, H.*, Robertson, M.J.*, Kleinhenz, A.L.W., Wingler, L.M., Capel, W.D., Latorraca, N.R., Lefkowitz, R.J., and Skiniotis, G. (2020). Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc. Nature 579, 297-302.
3. Liu, D.M., Chen, Q., Zhang, L., Hu,H., Yin, C.C. AgsA oligomer acts as a functional unit. Biochemical and Biophysical Research Communications, 2020. 530(1): p. 22-28.
4. Hilger, D.*, Kumar, K.K.*, Hu, H.*, Pedersen, M.F., O’Brien, E.S., Giehm, L., Jennings, C., Eskici, G., Inoue, A., and Lerch, M. (2020). Structural insights into differences in G protein activation by family A and family B GPCRs. Science 369(6503).
5. Gao, Y.*, Hu, H.*, Ramachandran, S.*, Erickson, J.W., Cerione, R.A., and Skiniotis, G. (2019). Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation. Mol Cell 75, 781-790 e783.
6. Koehl, A.*, Hu, H.*, Feng, D.*, Sun, B., Zhang, Y., Robertson, M.J., Chu, M., Kobilka, T.S., Laeremans, T., Steyaert, J., et al. (2019). Structural insights into the activation of metabotropic glutamate receptors. Nature 566, 79-84.
7. Kato, H.E.*, Zhang, Y.*, Hu, H., Suomivuori, C.M., Kadji, F.M.N., Aoki, J., Krishna Kumar, K., Fonseca, R., Hilger, D., Huang, W., et al. (2019). Conformational transitions of a neurotensin receptor 1-Gi1 complex. Nature 572, 80-85.
8. Koehl, A.*, Hu, H.*, Maeda, S.*, Zhang, Y., Qu, Q., Paggi, J.M., Latorraca, N.R., Hilger, D., Dawson, R., Matile, H., et al. (2018). Structure of the micro-opioid receptor-Gi protein complex. Nature 558, 547-552.
9. Qu, Q.*, Takahashi, Y.H.*, Yang, Y., Hu, H., Zhang, Y., Brunzelle, J.S., Couture, J.F., Shilatifard, A., and Skiniotis, G. (2018). Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex. Cell 174, 1117-1126 e1112.
10. Maeda, S.*, Koehl, A., Matile, H., Hu, H., Hilger, D., Schertler, G.F.X., Manglik, A., Skiniotis, G., Dawson, R.J.P., and Kobilka, B.K. (2018). Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun 9, 3712.
11. Krishna Kumar*, K., Shalev-Benami*, M., Robertson, M.J., Hu, H., Banister, S.D., Hollingsworth, S.A., Latorraca, N.R., Kato, H.E., Hilger, D., Maeda, S., et al. (2019). Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell 176, 448-458 e412.
12. Zhang, Y.*, Sun, B.*, Feng, D.*, Hu, H., Chu, M., Qu, Q., Tarrasch, J.T., Li, S., Sun Kobilka, T., Kobilka, B.K., et al. (2017). Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature 546, 248-253.
13. Ehsan, M., Ghani, L., Du, Y., Hariharan, P., Mortensen, J.S., Ribeiro, O., Hu, H., Skiniotis, G., Loland, C.J., Guan, L., et al. (2017). New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies. Analyst 142, 3889-3898.
14. Hu, H., Zhang, K., and Meng, X. (2016). Classification using diffraction patterns for single-particle analysis. Ultramicroscopy 164, 46-50.
15. Hu, H., and Meng, X. (2016). Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes. Eur J Transl Myol 26, 5805.
16. Zhang, K., Ezemaduka, A.N., Wang, Z., Hu, H., Shi, X., Liu, C., Lu, X., Fu, X., Chang, Z., and Yin, C.C. (2015). A novel mechanism for small heat shock proteins to function as molecular chaperones. Sci Rep 5, 8811.
17. Hu, H., Wang, Z., Wei, R., Fan, G., Wang, Q., Zhang, K., and Yin, C.C. (2015). The molecular architecture of dihydropyrindine receptor/L-type Ca2+ channel complex. Sci Rep 5, 8370.
