Hongli HU

Publications

Hongli HU
Title:

Assistant Professor

Education Background:
Ph.D. (Peking University)
B.Sc. (Nankai University)
Research

Cryo-EM structural biology; Membrane protein structure and function; GPCR; Novel drug discovery

PublicationsInfo

1.       Chen, G., X. Wang, Y. Ge, L. Ma, Q. Chen, H. Liu, Y. Du, R. D. Ye, H. Hu and R. Ren. (2020). Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther 5(1): 142.

2.       Staus, D.P.*, Hu, H.*, Robertson, M.J.*, Kleinhenz, A.L.W., Wingler, L.M., Capel, W.D., Latorraca, N.R., Lefkowitz, R.J., and Skiniotis, G. (2020). Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc. Nature 579, 297-302.

3.       Liu, D.M., Chen, Q., Zhang, L., Hu,H., Yin, C.C. AgsA oligomer acts as a functional unit. Biochemical and Biophysical Research Communications, 2020. 530(1): p. 22-28.

4.       Hilger, D.*, Kumar, K.K.*, Hu, H.*, Pedersen, M.F., O’Brien, E.S., Giehm, L., Jennings, C., Eskici, G., Inoue, A., and Lerch, M. (2020). Structural insights into differences in G protein activation by family A and family B GPCRs. Science 369(6503).

5.       Gao, Y.*, Hu, H.*, Ramachandran, S.*, Erickson, J.W., Cerione, R.A., and Skiniotis, G. (2019). Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation. Mol Cell 75, 781-790 e783.

6.       Koehl, A.*, Hu, H.*, Feng, D.*, Sun, B., Zhang, Y., Robertson, M.J., Chu, M., Kobilka, T.S., Laeremans, T., Steyaert, J., et al. (2019). Structural insights into the activation of metabotropic glutamate receptors. Nature 566, 79-84.

7.       Kato, H.E.*, Zhang, Y.*, Hu, H., Suomivuori, C.M., Kadji, F.M.N., Aoki, J., Krishna Kumar, K., Fonseca, R., Hilger, D., Huang, W., et al. (2019). Conformational transitions of a neurotensin receptor 1-Gi1 complex. Nature 572, 80-85.

8.       Koehl, A.*, Hu, H.*, Maeda, S.*, Zhang, Y., Qu, Q., Paggi, J.M., Latorraca, N.R., Hilger, D., Dawson, R., Matile, H., et al. (2018). Structure of the micro-opioid receptor-Gi protein complex. Nature 558, 547-552.

9.       Qu, Q.*, Takahashi, Y.H.*, Yang, Y., Hu, H., Zhang, Y., Brunzelle, J.S., Couture, J.F., Shilatifard, A., and Skiniotis, G. (2018). Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex. Cell 174, 1117-1126 e1112.

10.    Maeda, S.*, Koehl, A., Matile, H., Hu, H., Hilger, D., Schertler, G.F.X., Manglik, A., Skiniotis, G., Dawson, R.J.P., and Kobilka, B.K. (2018). Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun 9, 3712.

11.    Krishna Kumar*, K., Shalev-Benami*, M., Robertson, M.J., Hu, H., Banister, S.D., Hollingsworth, S.A., Latorraca, N.R., Kato, H.E., Hilger, D., Maeda, S., et al. (2019). Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell 176, 448-458 e412.

12.    Zhang, Y.*, Sun, B.*, Feng, D.*, Hu, H., Chu, M., Qu, Q., Tarrasch, J.T., Li, S., Sun Kobilka, T., Kobilka, B.K., et al. (2017). Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature 546, 248-253.

13.    Ehsan, M., Ghani, L., Du, Y., Hariharan, P., Mortensen, J.S., Ribeiro, O., Hu, H., Skiniotis, G., Loland, C.J., Guan, L., et al. (2017). New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies. Analyst 142, 3889-3898.

14.    Hu, H., Zhang, K., and Meng, X. (2016). Classification using diffraction patterns for single-particle analysis. Ultramicroscopy 164, 46-50.

15.    Hu, H., and Meng, X. (2016). Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes. Eur J Transl Myol 26, 5805.

16.    Zhang, K., Ezemaduka, A.N., Wang, Z., Hu, H., Shi, X., Liu, C., Lu, X., Fu, X., Chang, Z., and Yin, C.C. (2015). A novel mechanism for small heat shock proteins to function as molecular chaperones. Sci Rep 5, 8811.

17.    Hu, H., Wang, Z., Wei, R., Fan, G., Wang, Q., Zhang, K., and Yin, C.C. (2015). The molecular architecture of dihydropyrindine receptor/L-type Ca2+ channel complex. Sci Rep 5, 8370.