Biography

蒋成:香港中文大学(深圳)医学院助理教授(副研究员),博士生&博士后合作导师。中国化学会和美国化学会会员、深圳海外高层次人才。2016年获得澳大利亚新南威尔士大学博士学位,2017-2022年在牛津大学临床神经科学系(John Redcliffe 医院)从事博士后研究。主要研究方向为疑难疾病的生物标志物开发,特别是针对尚无有效标志物的神经退行性疾病(比如帕金森病)的精准诊断。2017-2022曾先后主持或共同主持包括John Fell FundThe Michael J. Fox Foundation Grant。凭借在高、低通量检测技术、算法及其应用在帕金森病标志物开发方面的工作,蒋成博士在20202022 年分别荣获牛津大学临床神经科学系Thomas Wills Early Career Researcher Prize(早期职业生涯研究学者奖)和 Recognition of Research Excellence Award(卓越科研奖)。现已在

(1) 开发技术平台方向发表论文:Chem Rev高被引文章, 2020最受读者喜爱的五佳论文, VIEW入选主封面论文, Micro-Nano Lett (高被引文章), the Innovation Medicine, Adv. Mater, Adv. Funct Mater, ACS AMI, Anal ChemACS Sens(ACS SENSORS十周年最受喜欢的论文之一)Nanoscale Horiz, Mater. Chem. Front, Biosens. Bioelectron, ACS Appl. Nano Mater, Dyes Pigm, Langmuir

2临床转化医学方向发表论文:Cell Reports Medicine, JAMA Neurology(神经科学顶级期刊, BBC 及Nature Reviews Neurology highlight); Mov. Disord (神经科学TOP期刊, 入选插图文章; J. Neurol. Neurosurg. Psychiatry (神经科学TOP期刊, 高被引文章);Brain (神经科学顶级期刊); EVCNA 等国际著名期刊以及应邀撰写两个BOOK Chapter 已获得国际专利(细胞外囊泡纯化技术及帕金森病标志物)授权2项。同时担任>30 SCI 杂志特邀审稿人以及Nano-Micro Letters (IF 26.6)Asian J Pharm SciIF 9.298),细胞外囊泡与循环核酸 (Extracellular Vesicles and Circulating Nucleic Acids, EVCNA) Brain-X BME MAT青年编委和Photonics, Micromachines等杂志客座编辑。目前在研项目包括国自然面上,广东省基础研究基金等多个项目。


Research

1) Functional Magnetic Architectures


2) Digital Chip


3) Solid-state & flexible sensory device with visualization research


4) Exosome in-depth profiling 

Awards and honors
  • 2022
  • 2020
<
  • 01

    2022

    Recognition of Research Excellence, Oxford

  • 02

    2020

    Early Career Researcher Prize, Oxford

>
Publications

已发表论文

第一作者& 通讯作者

 

1. Yan, S.,+ Jiang, C.,+ Janzen, A., Barber, T.R., Seger, A., Sommerauer, M., Davis, J.J., Marek, K., Hu, M.T., Oertel, W.H. and Tofaris, G.K., Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease. JAMA neurology.2023. 4:e234398. doi: 10.1001/jamaneurol.2023.4398. (Co-first author)

2. Zhou, Y., Yan, S., Dong, W., Wu, C., Zhao, Z., Wang, R., Duo, Y., Huang, Y., Xu, D. and Jiang, C.*, 2023. Biosensing strategies for amyloid‐like protein aggregates. BMEMat, p.e12053.

3. Yang C, Zhang W, Bai M, Luo Q, Zheng Q, Xu Y, Li X, Jiang C,* Cho WC,* Fan Z.* Edible plant-derived extracellular vesicles serve as promising therapeutic systems. Nano TransMed. 2023 Sep 1;2(2-3):100004.

4. Zhang, W; Lu, Y;   Su, C; Wang, Y; Wang, Yong-Fei; Zhang, Bo; Jiang, Cheng*; Guo, *   Keying; Xu, C*. Confinement-guided ultrasensitive optical assay with artificial intelligence for disease diagnostics. The Innovation   Medicine 2023; DOI 10.59717/j.xinn-med.2023.100023       (Correspondence)

5. Jiang, C* et al. New   insights of engineered extracellular vesicles as promising therapeutic   systems. Extracell Vesicles Circ Nucleic Acids 2023; 4:191-4 (Correspondence)

6. Yan S., Jiang, C.,   Davis.,   JJ, Tofaris., GK. Methodological considerations in neuronal extracellular   vesicle isolation for α-synuclein biomarkers. Brain 2023 (In   press) (Co-first author, IF 15.255)

7. Cheng, H., Chen, S., Li, M., Lu, Y., Chen,   H., Fang, X., Qiu, H., Wang, W., Jiang, C.,*    Zheng, Y.,*    (2022) Ultra-stable dual-color   phosphorescence Carbon-Dot@Silica material for advanced anti-counterfeiting. Pigment  and Dyes. 208, 110827. (Co-correspondence, IF 5.12)

8. Lu, Y., Chen, H., Cheng, H., Qiu, H.,   Jiang, C.,* Zheng, Y.,* (2022). Plasmonic Physical Unclonable   Function Labels Based on Tricolored Silver Nanoparticles: Implications for   Anti-Counterfeiting Applications. ACS Appl. Nano Mater. (10.1021/acsanm.2c01622).   (Co-correspondence)

9.Jiang, C.,* Fu, Y.,  Liu, G., Shu, B., Davis, JJ;* Tofaris, G.*   (2022). Multiplexed Profiling of Extracellular Vesicles for Biomarker   Development. Nanomicro Lett. 14:3 DOI:   10.1007/s40820-021-00753-w (First-author and   co-corresponding author, IF 26.6, Highly cited paper)

10. Qiu, H., Wang, W.,   Cheng, H.,   Lu, Y.,     Li, M.,   Chen, H.,   Fang, X.,   Jiang, C*., Zheng, Y.* (2022) Triple   Optically Modulated and Enzymatically Responsive Organic Afterglow Materials   for Dynamic Anti-counterfeiting. Mater. Chem. Front., DOI: 10.1039/D2QM00235C (Co-correspondence,   IF 6.482)

11. Fan, Z., Jiang, C.,,   Zhang, D.,* Chen, X.,*, Nie, L.,* (2022) Engineered Extracellular Vesicles   with Intelligent Core for New Generation of Nanomedicine. Nanoscale   Horiz. (Co-first author, IF 10.989)

12. Jiang, C., Hopfner, F; Berg, D; Hu, MT;   Pilotto, A; Borroni, B; Davis, JJ; Tofaris, G.* (2021) Validation of   α-synuclein in L1CAM-immunocaptured exosomes as a biomarker for the   stratification of Parkinsonian syndromes. Mov Disord. 36 (11),   2663-2669 (Editor’s choice: featured with   infographic, top medical journal)

13. Liu GZ,* Jiang C,* Lin XT, Yang Y.   (2021) Point-of-care detection of cytokines in cytokine storm management   and  beyond:  significance  and    challenges.  VIEW.  (Co-corresponding   author, doi.org/10.1002/VIW.20210003, featured   with front-cover image, IF 8.6)

14. Jiang, C., Wang, G X., Hein, R.,   Liu, N Z., Luo, X L.,* & Davis, J J* (2020). Antifouling Strategies for   Selective In Vitro and In Vivo Sensing. Chem. Rev. 120, 8,   3852-3889. (Highly cited paper & Top5 (out of   264) 2020 favourite Chemical Reviews)

15. Zheng, Y.,* Jiang, C.,  Ng, S. H., Lu, Y., Han, F., Bach, U.,   & Gooding, J. J.*  (2016).   Unclonable Plasmonic Security Labels Achieved by   Shadow-Mask-Lithography-Assisted Self-Assembly. Adv. Mater, 28,   2330–2336 

16. Jiang, C, Hopfner, F, Katsikoudi, A, Evetts,   S, Hein, R, Catli, C, Huang, Y, Wang, H; Ryder, J; Kuhlenbaeumer,G; Deuschl,   G; Padovani, A; Berg, D; Borroni, B;  Hu, M; Davis, JJ & Tofaris, GK* (2020).   Serum neuronal exosomes predict and differentiate Parkinson’s disease from   atypical Parkinsonism. J. Neurol. Neurosurg. Psychiatry 91,   720–729 (Top medical journal, IF 11.0)

17. Jiang, C., Alam, M. T., Silva, SM., Taufik,   S., Fan, SJ., & Gooding, J. J,* (2016). Unique sensing interface that   allows the development of an electrochemical immunosensor for the detection   of Tumor Necrosis Factor α in whole blood. ACS Sens, 1,   1432–1438

18. Fu, Y.,1 Jiang, C.,1   Davis,   J,* Tofaris, GK* (2020).  Facile   Impedimetric Analysis of Neuronal Exosome Markers in Parkinson’s Disease   Diagnostics. Anal Chem. 92, 13647–13651. (Co-first author)

19. Deng, M.,1 Jiang, C.,1   & Jia,   L.* (2013). N-methylimidazolium modified magnetic particles as   adsorbents for solid phase extraction of genomic deoxyribonucleic acid from   geneticallymodified soybeans. Anal. Chim. Acta, 771, 31–36. (Co-first   author)

20. Jiang, C., Alam, M. T., Parker,   S. G., Darwish, N., & Gooding, J. J.* (2016). Strategies to Achieve   Control over the Surface Ratio of Two Different Components on Modified   Electrodes Using Aryl-Diazonium Salts. Langmuir, 32, 2509–2517.  

21. Jiang, C., Alam, M. T; Fan S. J,   W. Y. F., Moraes. S., Liu G. Z., & Gooding, J. J,* (2017). Aryldiazonium   salt derived mixed organic layers: from surface chemistry to their   applications. J. Electroanal. Chem., 15, 265–278.

22. Jiang, C., Tanzirul Alam, M.,   Parker, S. G., & Gooding, J. J.* (2015). Zwitterionic Phenyl   Phosphorylcholine on Indium Tin Oxide: a LowImpedance   ProteinResistant Platform for Biosensing. Electroanalysis,   27, 884889.

23. Jiang, C., Xu., S, Zhang., S   & Jia, L.* (2012). Chitosan functionalized magnetic particle-assisted   detection of genetically modified soybeans based on polymerase chain reaction   and capillary electrophoresis. Anal. Biochem, 420, 1, 20-25.

 

其他共同作者论文

 

 

1. Su, Q;* Jiang, C; Gou, D;* Long, Y.*   (2021) Surface plasmon assisted fluorescence enhancing and quenching:   from theory to application.  ACS   Appl. Bio Mater. 4, 6, 4684–4705  

2. Kaurab, J., Jiang, C., & Liu. GZ*   (2019). Different Strategies for Detection of HbA1c Emphasizing on   Biosensors and Point of-Care Analyzers. Biosens. Bioelectron, 123,   1, 85-100. (IF 10.618)

3. Cao, CM., Zhang, Y., Jiang, C., Qi,   M., & Liu. GZ* (2017) Advances on Aryldiazonium Salt Chemistry Based   Interfacial Fabrication for Sensing Applications. ACS Appl. Mater.   Interfaces, 9 (6), 5031–5049. (IF 9.229)

4. Guan, Y., Jiang, C., Hu, C. & Jia, L*   (2010). Preparation of multi-walled carbon nanotubes functionalized magnetic   particles by sol–gel technology and its application in extraction of estrogens.   Talanta, 83(2), 337-343. (IF 6.057)

5. Taufik, S., Barfidokht, A., Alam, M.T., Jiang, C.,   Parker, S.G. & Gooding, J.J* (2016). An antifouling electrode based on   electrode–organic layer–nanoparticle constructs: Electrodeposited organic   layers versus self-assembled monolayers. J. Electroanal. Chem,   779, 229-235. (IF 4.464

6. Xu, S., Jiang, C., Lin, Y. and Jia, L* (2012).   Magnetic nanoparticles modified with polydimethylsiloxane and multi-walled   carbon nanotubes for solid-phase extraction of fluoroquinolones. Microchim   Acta, 179(3-4), 257-264.  (IF   5.833)

7. Zhang, X., Li, Q.,   Jin, X., Jiang, C., Lu, Y., Tavallaie, R., & Gooding, J. J.   (2015). Quantitative determination of target gene with electrical sensor. Sci   Rep, 5, 12539. (IF 4.379)

8. Zhang, S., Jiang, C., & Jia, L. (2011).   Tetrabutylammonium phosphate-assisted separation of multiplex polymerase   chain reaction products in non-gel sieving capillary electrophoresis. Anal   Biochem, 408(2), 284-288. (IF 3.365)

9. Sun, J., Wang, G.,*, Cheng, H., Lia, Q., Han,   Y., Jiang, C (2022) An antifouling electrochemical aptasensor based on   hyaluronic acid functionalized polydopamine for thrombin detection in human   serum. Bioelectrochemistry. doi.org/10.1016/j.bioelechem.2022.108073

10. Huang, S; Jiang, C; Mughal, MJ; Wang, G;  F Xing (2022) An In Vivo Fluorescence   Resonance Energy Transfer-based Imaging Platform for Targeted Drug Discovery   and Cancer Therapy. Front. Bioeng. Biotechnol.

11. Han, F; Wang, T; Liu, G; Liu, H; Xie, X;   Wei, Z; Jing Li, J; Jiang, C; He, Y; Xu, F.* (2022) Materials   with Tunable Optical Properties for Wearable Epidermal Sensing in Health   Monitoring. Adv Mater. doi.org/10.1002/adma.202109055

 

书籍章节

1. Liu GZ,* Jiang C. (2022). Chapter 19 Diazonium salts and   the related compounds for the design of biosensors. Book “Diazonium surface   chemistry and applications”. Wiley. (Doi.org/10.1007/978-3-031-04398-7_19,   invited Book Chapter)

2. Fan Z, Jiang C* (2022) Chapter 6 Engineered   extracellular vesicles as drug delivery systems for the next generation of   nanomedicine. (Accepted, invited Book Chapter)

 


已授权国际专利

(1) Method of Isolating A Selected Population Of Exosomes   (WO-2021094750-A1)

(2) Biomarkers for The Prediction and Identification of   Parkinson's Disease (WO-2021094751-A1)